Assessment of Cortisol, Brain-Derived Neurotropic factor, C - reactive protein, Interleukin-6 levels and cognitive decline after trauma exposure

Background: Studies have found that multiple neurobiological mechanisms are underlying the cause of Posttraumatic stress influence nervous and immune system leading to neurodegenerative psychiatric comorbidities. The present study aims assess evaluate serum Cortisol, C - reactive protein (CRP), Interleukin-6 (IL-6), Brain-Derived Neurotropic Factor (BDNF) levels cognitive decline among subjects with trauma exposure determine relationship between above-specified biomarkers. Methodology: Two groups (including natural disaster, any accident, physical and/or verbal violence, or stressful condition) in last twelve months were recruited. Groups majorly divided based on TSC-40 (Trauma Symptom Checklist 40) scores. Subjects a TSC score > 40 kept traumatized group, while those < included control group. A total 188 above age 18 recruited following inclusion criteria, cognition was measured using Six-Item Cognitive Impairment Test (6-CIT), samples obtained for cortisol, CRP, BDNF, IL-6 levels. Results: There significant difference BDNF (P<0.001) level subjects, i.e. 15.68 ± 3.55 ng/dl as compared controls 26.65 2.47 ng/dl; no CRP (ns) both slight increase controls, 4.29 1.50 mg/dl vs. 3.42 1.11 mg/dl. As indicated by 6-CIT score, more pronounced 8.54 2.13 group 5.0 1.81, positive (p<0.001). Conclusion: finding suggests traumatic is associated decline, whereas non-significant association